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12月06日16:10 柯衡明:Cyclic nucleotide phosphodiesterases and its application

988棋牌游戏,45棋牌游戏,10元可提现的棋牌:编号:jz-yjsb-2019-y077

988棋牌游戏,45棋牌游戏,10元可提现的棋牌:题目:Cyclic nucleotide phosphodiesterases and its application

主 讲 人:柯衡明   The University of North Carolina at Chapel Hill

988棋牌游戏,45棋牌游戏,10元可提现的棋牌:时间:20191206日(星期五)下午16:10

988棋牌游戏,45棋牌游戏,10元可提现的棋牌:地点:阜成路西校区教三楼348

参加对象:轻工科学技术学院全体师生,全校对988棋牌游戏,45棋牌游戏,10元可提现的棋牌:感兴趣的师生

主办单位:研究生院

承办单位:轻工科学技术学院

主讲人简介:

柯衡明教授,哈佛大学生物物理学博士,美国北卡罗来纳大学教堂山分校医学院的终身教授,美国NIH首席科学家,师从诺贝尔化学奖获得者William N. Lipscomb教授。柯教授在结构生物学研究方面取得了世界知名的成果,已经解出了PDE10类蛋白质的晶体结构。在CellScienceNature Struct. Biol.Proc Natl Acad Sci U S AJ Biol ChemJ Med Chem.DevelopmentBiochem. Pharmacol.Biochem J., J. Mol. Biol.等国际著名学术期刊上发表论文80余篇。是American Crystallographic AssociationAmerican Association for the Advancement of Science 委员,J. Biological Sciences, Current Bioactive Compounds 编委,以及Proc. Natl. Acad. Sci., J. Mol. Biol.,J. Biol. Chem.EMBO J.BiochemistryStructureProtein: structure, function and geneticsNature Structural Biology等顶级期刊的审稿人。

主讲内容:

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP  and cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides, their signalling pathways and, consequently, myriad biological responses in health and disease. PDE inhibitors are used clinically for treating the pathophysiological dysregulation of cyclic nucleotide signalling inerectile dysfunction, pulmonary hypertension, acute refractory cardiac failure, intermittent claudication and chronic obstructive pulmonary disease.